Formed in 2014 by cousins Scrim (stylized as $crim) and Ruby da Cherry, the duo initially rose to popularity on SoundCloud for their abrasive, self-produced beats, as well as their harsh lyrical content and themes prominently featuring substance abuse and suicidal ideation.

[7] In May 2019, they released their collaborative six-track EP with Blink-182 drummer Travis Barker entitled Live Fast, Die Whenever, which also featured Korn guitarist James Shaffer.

Arceneaux originally was inspired by T-Pain and Lou Reed to produce music, buying his first laptop which he used to start DJing with money gained from selling drugs.

[9] Raised in Metairie, Louisiana, Petrou's interest in music began when he was seven, playing violin and then drums when he was ten, eventually joining bands in middle school.

[10] Elaborating on this in an interview with Mass Appeal, Arceneaux states that "it was pretty much like cutting the hand, bleeding, and making a pact that there's no plan B, that if this doesn't happen by the time we're 30, I'm blowing my head off".

[6] The duo's first project together, a three-track EP named Kill Yourself Part I: The $uicide $aga, was released in June 2014 on SoundCloud and Bandcamp, attracting attention for their collaboration with notable underground rapper Bones.

[citation needed] After a number of collaboration EPs with fellow underground artist Black Smurf, their first full-length project titled Gray/Grey was released on March 3, 2015.

[19] In May 2019, the group put this rumor to rest with the release of their six-track EP Live Fast, Die Whenever in collaboration with Blink-182 drummer Travis Barker, and prominently featuring Korn guitarist James Shaffer.

[20] In July 2019, the duo started their first nationwide "Grey Day Tour", with guests Germ, City Morgue, Trash Talk, Denzel Curry, Shoreline Mafia, Night Lovell, Pouya, and Turnstile as openers.

[22][failed verification][clarification needed] Shortly after the release of the album, the duo began the Grey Day Tour 2021[23] along with other members of G*59, and with other artists, like Slowthai, Turnstile, and Yung Gravy.

In November 2021, the duo was awarded their first RIAA platinum single, as their hit song "...And to Those I Love, Thanks for Sticking Around" reached one million sales.

[24] In July 2022, the third studio album and 47th project from the duo, "Sing Me a Lullaby, My Sweet Temptation", its tracklist and covers were all announced on June 2, 2022, via an Instagram post.

On November 27, 2022, the duo alongside fellow G59 member, Germ, announced DirtiestNastiest$uicide,[25] a third and final addition to their DN$ trilogy.

[31] The second installment in the series, YIN YANG TAPES: Summer Season (1989–1990), was released on May 12, 2023, featuring Ghostemane on the track "Bloody 98".

On April 3, 2024, the duo announced GREYDAY2024,[36] the fifth year of their annual tour, featuring fellow G59 member Shakewell and other artists including Pouya, Denzel Curry, Haarper and Ekkstacy.

Petrou has released two solo mixtapes under the name Oddy Nuff da Snow Leopard; The Jefe Tape in 2012 and Pluto in 2014.

Many of their songs contain themes and insinuations of devil worship; however, as Arceneaux states in an interview with No Jumper, that their use of satanic imagery is simply a metonym for the negative effects of money, drugs, and other items that have the potential to manipulate people, and a dislike for organized religion.

[8] In September 2016, record producer Deadmau5 accused the duo of copyright infringement following the success of their song "Antarctica" (off of the 2016 mixtape Dark Side of the Clouds).

[38] The song samples parts of Deadmau5's "I Remember", with Kaskade; the DJ lambasted the duo for this, claiming that Suicideboys were "publicizing other people's intellectual property without consent".

[41] While the use of Three 6 Mafia has been met with reservations by some of its former members, particularly Gangsta Boo,[42] it has been embraced by others; founding member Juicy J has been vocal about his support and mentorship of Suicideboys and enlisted the duo to produce his mixtapes Highly Intoxicated and ShutDaF*kUp, featuring artists such as ASAP Rocky, Cardi B, Wiz Khalifa, and XXXTentacion.

Arceneaux has produced tracks for multiple artists, including Denzel Curry, Dash, and Juicy J; additionally, he states that he once held an in-house deal with Universal/Republic.

Arceneaux revealed in a No Jumper interview that at one point in his life he would lure people to him on Craigslist in order to rob them just to feed his addiction.