The series was created by husband and wife team Josh Goldsmith and Cathy Yuspa, who were also the writers and executive producers.

The show focuses on Eddie and Joy Stark (Brad Garrett and Joely Fisher), a couple married for 23 years who live in a suburb of Philadelphia, Pennsylvania.

The first two seasons often focus on the conflict between the Starks and their newlywed neighbors, Jeff and Steph Woodcock (Eddie Kaye Thomas and Kat Foster).

[11] The series went on hiatus beginning November 28, but returned with a new episode on a special night in March 2008 at 9:30 p.m.[12] Then in April, 'Til Death moved again to Wednesdays at 8:00 p.m. leading into Back to You.

[17][18] The surprise renewal was attributed to a significant licensing discount offered to Fox by the production company of 'Til Death (Sony Pictures Television), because it needed one more season to make the program viable for syndication.

[19][20] The fourth and final season premiered in October 2009 at a new time, Fridays at 8:30/7:30c, following a new sitcom, Brothers, starring former NFL player Michael Strahan.

[23] On July 26, 2011, it was announced that the show was picked up for syndication by affiliates The CW Plus, and WGN America, which debuted the program on September 12, 2011.