The series was licensed for an English-language release in North America by Tokyopop and in Australia and New Zealand by Madman Entertainment.

The story follows four +Anima children: Cooro, Husky, Senri, and Nana, who are brought together by their +Anima powers and search for others like themselves and a place to belong.

Written and illustrated by Natsumi Mukai, +Anima was serialized in MediaWorks's Shōnen manga magazine Dengeki Comic Gao!.

[a] The series finished its final installment in the March 2005 issue of Dengeki Comic Gao!, published on January 27, 2005.

[8] In North America, Tokyopop announced the English language release of the manga series in November 2005.