It has been serialized in Square Enix's seinen manga magazine Young Gangan since September 2009, with its chapters collected in twenty-four tankōbon volumes as of December 2023.

+Tic Elder Sister's narrative is centered around three students: Iroe Genma, Makina Sakamaki, and Hazuki Okamoto.

Written and illustrated by Cha Kurii [ja], +Tic Elder Sister started in Square Enix's seinen manga magazine Young Gangan since September 4, 2009.

[5] A spin-off manga, titled MeMeMeMeMeMeMeMeMeMenhera... (メメメメメメメメメメンヘラぁ...), has been published in two volumes released on November 25, 2016,[6] and August 25, 2020.

[7] A second spin-off, titled Aoikokoro ga chikyū o waru (アオイココロが地球を割る, Aoi Kokoro Breaks the Earth), was released on May 25, 2016.