It is broadcast from the network's studios in Miami, Florida, and is hosted by Raúl González, Jessica Rodríguez, Jomari Goyso, Karla Martínez, Alan Tacher, Francisca Lachapel, Ana María Canseco, and Satcha Pretto.

Among the permanent and occasional contributors of the show are Dr. Mario Lovo (immigration), Ariel Coro (technology expert),[2] Claudia Molina (exercise), Adriana Martin (fitness and lifestyle),[3] Alejandro Chabán (weight loss), Ismael Cala, María Marín, Alberto Sardiñas (motivation), Laura Posada (lifestyle)[4] among many others.

maintains more of a focus on interviews, and entertainment and feature stories; news headlines are generally limited to a segment that airs each half-hour, and national weather segments only appear once an hour during the first three hours of the broadcast (compared to the half-hourly weather updates that appear on other national morning news programs).

Despierta América is known for coining the catch phrase, "échate pa' acá" ("Come here"), which is a segment regarding news and gossip about Latin entertainers.

Despierta América has since developed its own brand and style of reporting news of various genres, such as immigration, sports, consumer, health, lifestyle, fashion, beauty and entertainment content.