[1] He was assigned to the Dominican Summer League Blue Jays for the 2012 season, where he pitched to a 5.40 earned run average (ERA), 13 strikeouts, and 13 walks in seven games totaling 112⁄3 innings.

[2] He remained with the DSL Blue Jays in 2013, pitching 262⁄3 innings and posting a 0–1 win–loss record, 3.04 ERA, and 43 strikeouts.

[2] Perdomo began the 2015 minor league season with the Rookie-Advanced Bluefield Blue Jays, and later earned a promotion to the Short Season-A Vancouver Canadians.

[2] Continuing to progress through the Blue Jays minor league system, Perdomo was assigned to the Class-A Lansing Lugnuts to open the 2016 season.

[4] Perdomo made 25 starts and two relief appearances for the Lugnuts in 2016, and posted a 5–7 record, 3.19 ERA, and 156 strikeouts in 127 innings.

[2] He played the entire 2017 season with the Advanced-A Dunedin Blue Jays, and went 5–6 with a 3.70 ERA and 65 strikeouts in 751⁄3 innings.

[13] He was assigned to the Triple-A Indianapolis Indians to begin the 2023 season, where he made 20 appearances and registered a 3.18 ERA with 35 strikeouts in 22+2⁄3 innings pitched.

[14] On July 25, Perdomo surrendered a home run to San Diego Padres outfielder Juan Soto.