In a 2022 interview, she explained, "I have three imbalances: I come from an indigenous community, I am a woman, and I am a lesbian – things that have been stereotyped and placed in an emerging situation of survival.

Ángeles Cruz is originally from Villa Guadalupe Victoria in San Miguel el Grande [es], a mostly indigenous community high in the mountains of Oaxaca.

[6] Cruz studied at the Miguel Cabrera Center of Artistic Education in Oaxaca, and later completed a licentiate in acting at the INBA Theater Art School in Mexico City.

Her first film as an actress was the Swedish-Danish drama La hija del puma about massacres that occurred in Guatemala against the indigenous people.

[8] She continued with the shorts La carta and Arcángel, followed by her first feature, Nudo Mixteco, starring Sonia Couoh [es] and Noé Hernández, which tells three stories of women living in indigenous communities in Oaxaca.