With the construction from 1970 to 1973 of a new location on rue Pirandello on the former site of the Delahaye automobiles factory (1898–1954), the ENCPB diversified its courses with the creation of classes préparatoires aux grandes écoles in the sections of MP, PC, BCPST and TB.

[1] The ranking is based on three criteria: the bac results, the proportion of students who obtain their baccalauréat after spending their last two years at the establishment, and the added value (calculated based on the social origin of the students, their age, and their national diploma results).

In 2015, the magazine L'Étudiant gave the following rankings for 2014 : In 1984, the ENCPB adopted the reforms to higher education, and offered a national diploma of Brevet de technicien supérieur (BTS), creating sections for: The also offered technological baccalauréats (as they are now known): They also offered post-BTS courses from 1984 to 2007, which became "professional licences": The ENCPB have developed partnerships with the École normale supérieure de Cachan and the Université Paris VII allowing students to study at these institutions, but also with a training centre for technical teachers for the Kingdom of Morocco in chemical engineering.

After the death in 2007 of physician Pierre-Gilles de Gennes, Nobel Prize in Physics laureate, the ENCPB was renamed "lycée Pierre-Gilles-de-Gennes - ENCPB" after him, and became a general and technological lycée with the development of a general S (SVT and SI) stream parallel to the lab technology stream.

In 2010, the school was used for scenes in the telefilm Obsessions by Frédéric Tellier where the laboratories stand in for "Laboratoire de la police scientifique".