The first lessons began in the fall of 1969, on an experimental basis, in Building D adjacent to the École Centrale de Lille, at the newly established University of Lille-1.

Six years later, on February 14, 1980, EUDIL was authorized to award engineering degrees through continuing education for the GTGC and IMA departments initially, and on October 1, 1990, for all its other departments (up to that point, French students were required to complete a "classe préparatoire" in order to join an engineering college).

In 1989, EUDIL, along with the University Center for Sciences and Technology in Clermont-Ferrand, ISIM in Montpellier, and ISTG in Grenoble, decided to come together to gain better visibility at the national and international levels.

In 1992, the School of Production Systems Operations Engineering (IESP) was established at the University of Lille 1 in response to the call from industrial partners (seven original partners and two professional sectors: metallurgy and chemistry) to provide training, through apprenticeship and continuous education, for production engineers with capabilities in both technical and management aspects.

In 1994, the "production" specialization degree was established in partnership with the Institute of Engineering Techniques for the Industry of Nord Pas-de-Calais.

The decree formalizing the merger of EUDIL, IAAL, and IESP and the creation of the University Polytechnic School of Lille was published in the official journal on April 4, 2002.

In September of the same year, the first official intake of the University Polytechnic School of Lille took place, offering 9 majors.

Founded in 2016, it is a part of the largest student movement in France, the National Confederation of Junior Enterprises.

It operates as a consulting firm and aims to apply the knowledge acquired by future engineers in school to real projects for businesses (small and medium-sized enterprises as well as large corporations).