The usual spiritual and academic Jesuit training led him to receive sacerdotal ordination on 24 August 1946.
After further studies involving Syriac he was appointed Professor of Church History and of Patristics at the Kurseong Saint-Mary's Jesuit Theologate in West Bengal[10] where he undertook research into the history of eastern church rites (notably in the Syrian Catholic tradition).
[11][12] Hambye's History of Christianity in India was well received in the 1970s, but some of his contemporary scholars, such as Stephen Neill, were less impressed.
[13] When work on the St. Thomas Christian Encyclopaedia of India commenced in 1970 by George Menachery he was along with Paul Verghese, later Paulos Mar Gregorios, one of the prominent consultants.
[15] In Kerala Hambye was actively involved in ecumenism between Saint Thomas Christians, Syrian Orthodox and Roman Catholics in India.