Prior to his appointment, he occupied different positions: senior advisor to the World Bank Executive Director (2017); advisor to the World Bank Executive Director (from 2011 to 2017)[1]; senior economic advisor to the Rwandan Ministry of Finance and Economic Planning; director general of National Development Planning and Research in Ministry of Finance and Economic Planning; senior lecturer at the former National University of Rwanda (now University of Rwanda) until 2010; head of Department of Agricultural Economics at the same university, independent consultant and project manager.

[4][5] Ngirente has overseen policy changes which aim to invigorate Rwanda's economy through expanded research grants,[6] transportation infrastructure[7] and education[8] among other departments.

Campaigns to encourage Rwandans to pay their taxes and preserve the environment have also been started with the intention of creating a more sustainable future both economically and environmentally.

[9][10] As part of his duties as a representative of Rwanda, Ngirente has traveled the globe campaigning for increased foreign investment in the nation.

[11] Ngirente has also traveled across Africa advocating for family planning efforts across the continent.