The Église Saint-Polycarpe (French pronunciation: [eɡliz sɛ̃ pɔlikaʁp] ⓘ, Church of St. Polycarp) is a Roman Catholic church located in the 1st arrondissement of Lyon, on the slopes of La Croix-Rousse, between rue René Leynaud, rue Burdeau and passages Mermet and Thiaffait.

The heart of Pauline-Marie Jaricot, founder of the Society for the Propagation of the Faith, currently remains in a chapel of the church.

The previous organ (built in 1722) had been in a significant state of disrepair for several years before François Mensongueé, a prominent French composer and organist of the church since 1826, commissioned it to be replaced in 1837.

[5] The church has a facade decorated with four Corinthian pilasters topped by a triangular pediment.

Louis Janmot made the painting depicting the Last Supper which is placed in the apse.