After meeting him in person through a mutual friend,[7] Radigue started her music education under Schaeffer and Pierre Henry at Studio d'Essai de la Radiodiffusion Nationale in Paris on 1955.

Around 1970, Radigue created her first synthesizer-based music in a studio she shared with Laurie Spiegel on a Buchla synthesizer installed by Morton Subotnick at NYU.

After that work's premiere at Mills College at the invitation of Robert Ashley, a group of visiting French music students spoke to her about Tibetan Buddhism, a subject she found fascinating and began investigating upon her return to Paris.

[14] After investigating Tibetan Buddhism, she quickly converted and spent the next three years devoted to its practice under her guru Tsuglak Mawe Wangchuk (the tenth incarnation of Pawo Rinpoche),[15] who subsequently sent her back to her musical work.

First she composed the Songs of Milarepa, followed by Jetsun Mila, an evocation of the life of this great master; the creation of these works was sponsored by the French government.

The work was influenced as much by the Bardo Thodol (aka Tibetan Book of the Dead) and her meditation practice, as by the deaths of Tsuglak Mawe Wangchuk and of her son Yves Arman.

In his AllMusic review, "Blue" Gene Tyranny described Trilogie de la Mort as a "profound work of electronic music".

[19] In 2001, on request from electric bassist and composer Kasper T. Toeplitz, she created her first instrumental work, Elemental II,[20] which she took up again with The Lappetites, a laptop improvisation group comprising Antye Greie/AGF, Kaffe Matthews and Ryoko Akama.

The second part of Naldjorlak for the two basset horn players Carol Robinson and Bruno Martinez, was created in September 2007 at the Aarau Festival (Switzerland).