Épinay-sur-Seine (French pronunciation: [epinɛ syʁ sɛn] ⓘ, literally Épinay on Seine) is a commune in the Seine-Saint-Denis department, in the northern suburbs of Paris, France.

It is located 11.3 km (7.0 mi) from the center of Paris.

The church of Notre-Dame-des-Missions-du-cygne d'Enghien, designed by Paul Tournon, may be found in the commune.

Francis, Duke of Cádiz (13 May 1822 – 17 April 1902), king consort of Spain, took up residence at the château of Épinay-sur-Seine in 1881 until his death in 1902.

Charles de Gaulle Airport is located about 13 km (8.1 mi) away from Épinay-sur-Seine.