On January 18, 2012, he stepped up and fought former two-time world heavyweight title challenger Chris Arreola.
Two and a half years later in May 2014, Molina scored his biggest professional career win by stopping former world heavyweight title challenger DaVarryl Williamson in five rounds.
Molina scored the biggest win of his entire professional career in April 2016 by stopping former two-weight world champion Tomasz Adamek in the tenth round.
Later that year, on December 10, he challenged for the IBF heavyweight title against champion Anthony Joshua in Manchester, England.
On May 22, 2018, Molina was suspended from fighting in the United Kingdom for two years by the UK Anti-Doping organisation after testing positive for the prohibited substance dexamethasone, a substance that the World Anti-Doping Agency lists as being prohibited during the "in competition" period only,[2] following his December 10, 2016 world title fight with Anthony Joshua.