It connects the commune of Bezons in the north to the Porte de Versailles Métro station in Paris in the south, serving Hauts-de-Seine and its La Défense business district.

The initial section between La Défense station and Issy–Val de Seine station, opened in July 1997, uses a former heavy rail line converted into light rail, whereas the further extensions on both ends opened in November 2009 and November 2012 feature segregated on-street running.

Line 2 is operated by the Régie autonome des transports parisiens (RATP) under the authority of Île-de-France Mobilités (IDFM).

The line's success (115,000 people use it daily) led to its Tramway Français Standard (TFS) rolling stock to be replaced starting in 2002 by Alstom Citadis trams; the TFS rolling stock was transferred to Île-de-France tramway Line 1 to increase its capacity.

With the extension to Porte de Versailles and the line crossing several intersections, the RATP had each tram's front and rear coupler covered, so that in the event of a collision with a pedestrian, the damage sustained by the person would be less severe.