Óscar Eduardo Henríquez [en-ree'-kayz] (born January 28, 1974) is a Venezuelan former relief pitcher in Major League Baseball who played for the Houston Astros (1997), Florida Marlins (1998) and Detroit Tigers (2002) in parts of three seasons spanning 1997–2002.

During the 1996 season he pitched with the Kissimmee Astros of the Gulf Coast league and ranked fifth on the team in strikeouts with 40.

In 1995, Henríquez was diagnosed with myasthenia gravis, a rare disorder that affects the nervous system and causes muscle weakness.

[1] In a 49-game career, Henríquez posted a 1–2 record with a 6.06 ERA and two saves, including 45 strikeouts and 30 walks in 52 innings of work.

In between, Henríquez played winter ball with the Cardenales de Lara, Navegantes del Magallanes and Tiburones de La Guaira clubs of the Venezuelan League in 12 seasons spanning 1992–2006, and also pitched for the Hyundai Unicorns of Korea Professional Baseball in 2001.