The Östergötland Infantry Regiment (Swedish: Östgöta infanteriregemente) was a Swedish Army infantry regiment with origins tracing back to the 16th century.

The regiment's soldiers were recruited from the province of Östergötland.

The regiment originated in 16th century Östergötland as fänikor (companies).

In 1619, these units—along with the fänikor from nearby Jönköping County—were organised by Gustav II Adolf into the Östergötland Grand Regiment, where 9 out of 24 companies were recruited from Östergötland.

The reorganisation and renaming to "life grenadier" was done because of the regiment's achievements during the 1788 Russo-Swedish War.