Cities and towns are marked in bold: Chabařovice - Chlumec - Chuderov - Dolní Zálezly - Habrovany - Homole u Panny - Libouchec - Malé Březno - Malečov - Petrovice - Povrly - Přestanov - Řehlovice - Ryjice - Stebno - Tašov - Telnice - Tisá - Trmice - Ústí nad Labem - Velké Březno - Velké Chvojno - Zubrnice Ústí nad Labem District borders Germany in the north.

The terrain is very varied—mostly hilly except in the west, and divided by the Elbe river valley.

The territory extends into four geomorphological mesoregions: Central Bohemian Uplands (most of the territory), Most Basin (west), Ore Mountains (north) and Elbe Sandstone Mountains (a small part in the northeast with the Tisá Rocks).

The highest point of the district is the mountain Rudný vrch in Telnice with an elevation of 796 m (2,612 ft), the lowest point is the river bed of the Elbe in Povrly at 130 m (430 ft).

The largest employers with headquarters in Ústí nad Labem District and at least 1,000 employees are:[5] The largest industrial employers with its headquarters in Ústí nad Labem District and at least 500 employees are:[5] The D8 motorway from Prague to Ústí nad Labem and Czech-German border passes through the district and constinues further to Dresden.