Ústí nad Labem Region or Ústecký Region (Czech: Ústecký kraj) is an administrative unit (kraj) of the Czech Republic, located in the north-western part of the historical land of Bohemia, and named after the capital, Ústí nad Labem.

Between the high escarpment of the Ore Mountains range and the Bohemian Central Uplands with many volcanic hills, there are vast areas devastated by surface coal mining (the Most Basin), partly being recultivated into an artificial landscape with ponds, plains and groves.

The Ústí nad Labem region has the third youngest population; the average age is 42.0 years.

[3] The composition of the population according to nationality is: The table shows cities and towns in the region that had more than 10,000 inhabitants (as of 1 January 2024).

The Bohemian Central Uplands and Říp Mountain (which is, according to legend, associated with the earliest Czech ancestors arriving in Bohemia) are both located in this area.

Other main rivers in the region include Ohře, Bílina, Ploučnice and Kamenice, all tributaries of the Elbe.

The largest water area is the Nechranice reservoir built on the Ohře River in the western part of the region.

[9] Historically, the economic importance of the Ústí nad Labem Region lay in its reserves of raw materials, especially deposits of brown coal, quality glass and foundry sands and building stone.

The brown coal basin stretches under the hillsides of the Ore Mountains from Ústí nad Labem to Kadaň.

The region is part of the Black Triangle, an area of heavily industrialization and environmental damage on the three-way border of Poland, Germany, and the Czech Republic.

Recently, the area around Most has become known as a wine-growing region, in which wine is grown mainly on lands that were reclaimed after brown coal mining.

Ústí nad Labem Region is crossed by railway lines connecting Berlin via Prague to Vienna or Budapest, as well as the Elbe water way.