The Üç Şerefeli Mosque was commissioned by Ottoman sultan Murad II (r. 1421–1444, 1446–1451), and built between 1438 and 1447.

[2] The two blue and turquoise underglaze-painted tile panels in the tympana of the windows were probably produced by the same group of tilemakers who had decorated the Yeşil Mosque (1419–21) in Bursa where the tiles are signed as "the work of the masters of Tabriz" (ʿamal-i ustadan-i Tabriz).

The running pattern of the Chinese influenced floral border tiles is similar to those in the small Muradiye Mosque in Edirne.

[7][8] In the Şakaiki Numaniye Taşköprüzade relates how 'Certain accursed ones of no significance' were burnt to death in front of the mosque by Mahmut Paşa who accidentally set fire to his beard in the process.[9][when?]

Blair and Bloom suggest that it is a grander-scale version of the Saruhanid congregational mosque or Ulu Cami (1367) in Manisa, a city with which Murad II was familiar.

[14] Kuban suggests that the mosque's spatial design evolved from the importance of the domed space commonly found in front of the mihrab in early Islamic architecture, as well as from the influence of earlier single-domed Ottoman mosques.