[1] Today, it is owned and administered by the Health and Education Foundation (Turkish: Sağlık ve Eğitim Vakfı, or SEV) along with other former ABCFM institutions in Turkey.

The site in Bağlarbaşı [tr], an area of Üsküdar, a neighbourhood on the Asian part of İstanbul, was originally the American College for Girls.

ACG vacated the Baglarbaşı site in 1914 and moved to Arnavutköy, a neighborhood on the European side of Bosphorus, leaving the Baglarbaşı campus empty from 1914 to 1921 except for the years 1914–1915 when the buildings of the school were used as an orphanage by the Americans and the years 1915–1918 when the Turkish army used the school as a barracks.

When Üsküdar American Academy for Girls was looking for a new location in Istanbul, it moved to the present site in Baglarbaşı in the early 1920s.

There was a chapel in the place of the present gymnasium in which Sunday worship services were held for the local Christian community.

Üsküdar American Academy experienced a radical change in 1990 when it admitted boys for the first time into the Orta Prep class.

With the help of USAID grants, the Sabancı Holding, supportive parents, and the Health and Education Foundation (SEV) physical changes have also continued with the building of a gymnasium, the restoration of Bowker and Barton Halls, and the construction of Morgan Hall, the science, math and computer building.

[7] Situated on a hill in the residential district of Üsküdar, the school campus includes 8 buildings sited on 18,000 square meters.

[8] Üsküdar American Academy has a variety of buildings in their campus, most having dedicated subjects taught in them.

[4][11] Huntington Hall began construction in 1955 when Jessie Martin was acting as the principal for her final time.

The building was named after George Huntington and his wife Mrs. Clarke who both contributed generously towards scholarships for more than twenty-five years.

[9] Huntington Hall is home to the faculty building, the auditorium, and the iconic organ which has been Üsküdar American Academy property since 1950.

[12] On 9 January 1996, Özdemir Sabancı, a businessman and President of SEV's Trustees Governing Council was murdered.