Đorđe S. Simić (28 February 1843, in Belgrade – 11 October 1921, in Zemun), was a Serbian politician and diplomat.

Upon graduation in Belgrade, he studied the state sciences in Berlin, Heidelberg and Paris.

He was hired as a civil servant at the Ministry of Foreign Affairs of Serbia and was head of its political department from 1867 to 1882.

In internal politics, the government improved finances and armament of the Serbian Army after the threats to the regional security provoked by the Greco-Turkish War of 1897.

[2] Đorđe S. Simić translated in 1883 the capital work of Benjamin Constant -- Principes de Politique Applicable a Tous Les Gouvernements -- on the principles of the political and ministerial responsibilities, considered a reference work by the elite of the Radical deputies.