The railway is the main freight and passenger train route from the Aegean region to Central Anatolia.

[2] Today the line is owned by the Turkish State Railways.

TCDD Taşımacılık operates regional and inter-city passenger service from İzmir to Uşak and Afyon, and further to Konya.

TCDD Taşımacılık also operates frequent freight trains, mostly from the industrial Aliağa region into central Anatolia.

Since 2018 Omsan operates bulk freight trains from the port of Aliağa to Kayseri, using the railway.