[1] The first documented history of the town is preserved in the privileges issued by King Alexander Jagiellon in Radom on May 10, 1505; thus releasing Łosice from under the Ruthenian and Lithuanian city laws, and giving it more progressive Magdeburg rights.

Throughout the 16th century the town enjoyed a period of economic development, with most inhabitants living off trade in leather, furs, and salt; as well as crafts, and a variety of services.

According to a 1580 registry, there were 47 carpenters, 32 tailors, 20 bakers, 10 butchers, 7 stove fitters, and 4 blacksmiths in the town, not to mention millers, a locksmith, a goldsmith and a weaver.

Before and during the January Uprising against the Russian rulership, local doctor Władysław Czarkowski led a unit of several hundred conspirators in an attack against the garrisons.

On September 12, 1939, during the joint German-Soviet invasion of Poland which started World War II, the town was taken over by the Germans, but shortly thereafter it was transferred to the Soviet Union.

On August 22, 1942, SS men and Ukrainian policemen raided the ghetto in the town and marched its Jewish inhabitants to Siedlce, killing about 1,000 people on the way, and the remaining 5,500 Jews were loaded onto freight cars and sent to the Treblinka extermination camp.

Just a few Jews survived the Nazi extermination camps and returned to Łosice in 1945, but they were violently expelled by the Polish citizens of the town, who took over the Jewish property.

The complex is located near the municipal park, built at the site of the former Jewish cemetery which was destroyed by Nazi Germany during World War II.