He was also selected for four tournaments during his time with the national team, playing in three UEFA European Championships and the 2018 FIFA World Cup.

[5] Piszczek's father, Kazimierz, the coach of the local football club of Goczałkowice-Zdrój, decided to bring him to one of the training sessions at the age of about 7–8.

In 2001, he joined Gwarek Zabrze, coached by Wincent Sosiński, where he broke many goalscoring records at junior level and in 2003 won the Polish youth championship.

Hertha BSC was attracted by his performances and promptly signed Piszczek in 2004, but then immediately loaned him out to Zagłębie Lubin.

He made his debut on 16 October 2004, in a 7–0 win against GKS Katowice, scoring and assisting a goal for Wojciech Łobodziński in the process.

[citation needed] In the fall of 2007, after three years with Zagłębie Lubin, Hertha recalled Piszczek back to the club.

At Hertha, Piszczek initially played as an offensive midfielder or on left wing, but in his second season, he started to appear at right-back after an injury to Arne Friedrich.

[18] On 20 May 2020, Piszczek pushed back his retirement plans by signing a one-year contract extension with Borussia Dortmund, keeping him at the club until 2021.

[19] In May 2021, Piszczek announced his return to his hometown club LKS Goczałkowice-Zdrój,[20] where he had established a branch of Borussia Dortmund's academy in 2019.

[26] On 29 July 2011, the Polish Football Association gave a six-month suspension on Piszczek for participation in the fixing of a 2006 match against Cracovia, in which he did not play.

[3] In November 2019, Piszczek was named to the national team for Euro 2020 qualifying matches against Israel and Slovenia, starting in the latter which was dubbed his farewell game.

[42] On 27 June 2024, Piszczek was announced as the new assistant manager of Borussia Dortmund, joining the staff of his former teammate Nuri Şahin.

[46] On 7 September 2024, a special Borussia Dortmund legends farewell match was held in order to pay tribute to Piszczek and his compatriot Jakub Błaszczykowski who helped shape some of the most successful years in the club's history between 2010 and 2015.