Ōsaki Station (大崎駅, Ōsaki-eki) is a railway station in Shinagawa, Tokyo, Japan, jointly owned and operated by East Japan Railway Company (JR East) and Tokyo Waterfront Area Rapid Transit (TWR).

Ōsaki is one of the stations on the Yamanote Line loop where trains are put into and taken out of service.

Unlike most other stations with service from multiple different transport companies, at Ōsaki the Rinkai line and JR services are behind the same fare gates, and it is possible to change between JR and Rinkai lines without exiting and re-entering.

Passengers using Suica or another IC card will be charged the combined fare when they exit.

Toilet facilities are located inside the ticket barriers, close to the north gate.