[2] Arzruni (also transliterated as Artsruni), whose family name belongs to an ancient Armenian nobility, was born in Istanbul, Turkey.

He moved to New York City in 1964 to study further at the Juilliard School of Music on a scholarship from the Calouste Gulbenkian Foundation.

Motivated by ethnic awareness in the United States, Arzruni continuously investigates the musical roots of his Armenian heritage.

Arzruni has given command performances at the White House, as well as the British, Danish, Swedish, and Icelandic courts.

[14] In 2017, 2019, and again in 2022 and 2024, Arzruni visited various provinces of Armenia, as well as the Republic of Artsakh, coaching young musicians and performing in recitals.