Žepče (Serbian Cyrillic: Жепче) is a town and municipality located in Zenica-Doboj Canton of the Federation of Bosnia and Herzegovina, an entity of Bosnia and Herzegovina.

The town was first mentioned in 1458 in a charter issued by the Bosnian king Stjepan Tomašević, "... Pissanna Žepču va ljetu 1458. oktombrija 14.

In 2001 the following Croat villages from the municipalities of Maglaj and Zavidovići merged with the municipality of Žepče to form one entity with Croat majority: Adže, Pire, Ponijevo, Matina, Ljubatovići, Grabovica, Čusto Brdo, Komšići, Radunice, Globarica, Brankovići, Donji Lug, Gornji Lug, Vrbica, Debelo Brdo, Osova, Vinište and Gornja Lovnica.

The town is home to local football club NK Žepče.

Una-Sana  Central Bosnia Posavina  Herzegovina-Neretva Tuzla  West Herzegovina Zenica-Doboj  Sarajevo Bosnian Podrinje Canton 10