Situated in Sector 1, the boulevard runs as a northward continuation of Calea Victoriei.

The road was created in 1832 by Pavel Kiselyov, the commander of the Russian occupation troops in Wallachia and Moldavia.

The area was not affected by the Ceaușima systematization plans and demolitions of Nicolae Ceaușescu, and has many pre-World War II residences.

Victory Square (Piața Victoriei) and Free Press Square (Piața Presei Libere) stand at its two extreme points.

Notable buildings on Șoseaua Kiseleff include: Also along Șoseaua Kiseleff one finds the embassies of Belarus, Canada, Peru, and Russia, as well as the residence of the Ambassador of the United States to Romania.