Its nearest equivalent, the .35 Whelen, was still a wildcat in 1965, though the .358 Norma Magnum had been commercialized six years prior.

[3] Though the Remington 600 and 660 chambered for the cartridge offered an excellent power-to-weight ratio, the combination failed to attain commercial success.

The .350 Remington Magnum is a powerful cartridge primarily intended for use in "brush guns," which can readily be maneuvered in environments where hunting opportunities appear and disappear quickly at relatively close ranges.

The .350 Remington Magnum is capable of taking any game animal on the North American continent effectively and humanely.

Ballistically it is almost identical to the popular 9.3×62mm rifle cartridge, which has achieved widespread acceptance in African and European hunting fields.