Intended primarily as a silhouette cartridge, such high velocity and energy levels have hunting applications.

[2] SAAMI pressure level for this cartridge is set at 40,000 pounds per square inch (280 MPa).

[4][5][6] Despite the cartridge's good performance, the higher pressure and velocity caused flame cutting to the top strap and erosion of the forcing cone, due to the use of light 110 and 125 grains (7.1 and 8.1 g) bullets, therefore it has since been dropped by all manufacturers who chambered revolvers in this cartridge.

[7] Single shot pistols and rifles (i.e. Thompson/Center Contender) are still available in this caliber, and remain popular among handloaders.

[9] In the movie, Flypaper (2011), Wyatt "Jelly" Jenkins (Pruitt Taylor Vince) uses a Dan Wesson Model 40 VH which is chambered in .357 Remington Maximum as his main sidearm, for the majority of the film.