Slight variations in charge weight in the same case led to the mistaken belief these were different rounds, when in fact they were not.

[1] Designed for black powder, the .50-110 was also available in a potent smokeless loading, comparable to British elephant rounds.

[1] In power, the standard load was comparable to the contemporary British .500 Black Powder Express.

[2] It is sufficient for elk, deer, moose, and bear at medium ranges or in woods,[3] and thin-skinned African game, but not dangerous animals such as elephants.

The high-velocity smokeless load was in a class with the .444 Marlin,[4] and its power exceeded the .348[5] and .358 Winchester.