Players can use the stylus, D-Pad and touch screen or Wii Remote to test their reflexes in action minigames like racing and skydiving, take on sporting events such as basketball, curling, and archery, strategize with tank and space combat games, or play match three, Sudoku, and jigsaw puzzles.

Gamers who set high scores earn gold coins that can be used to unlock other activities, and those looking for multiplayer action take on friends in multi-card wireless play.

When players start, there are only 10 games unlocked (Basketball, Tornado Hockey, Circus, Bouncer/Foot and the Ball, Sushi, Curlers, Sky Hunter, Darts, Card Castle (Dirty Gold in the WiiWare version) and Aquarium), and the 91 other minigames must be unlocked, with later minigames requiring a higher price.

In 2009, Atlus U.S.A., Inc. secured the North American publishing rights from Nordcurrent for 101-in-1 Explosive Megamix for Nintendo DS.

[11] Dan Pearson of Eurogamer gave the game a 4/10 and stated "There is so little replay potential here, so little urge to top high scores or perfect shoddy make-do attempts, that completing each task feels more of a relief than an achievement.".