[1] In 1813, the regiment was shipped overseas to the Canadian Frontier, and was garrisoned in Quebec City,[2] where it took part in the War of 1812.

During the 1812 war, the flank companies (Grenadier and Light Infantry) saw service at notable battles, included: Patteron's Creek, Lundy's Lane, the Siege of Fort Erie and the Niagara Campaign.

[9] During the Battle of Lundy's Lane, the line companies of the regiment formed part of the First Brigade under Colonel Hercules Scott, at Twelve Mile Creek, while the flank companies were part of the Third (Light) Brigade under Lieutenant Colonel Thomas Pearson, encamped near Four Mile Creek.

After making several attempts to capture the lines, though suffering heavy casualties and their location being given away by forward pickets, the attack column fell back.

Yet another attack was ordered, and the sailors and marines of the column made it past the breastworks, but after a volley and bayonet charge by the 19th U.S. Infantry Regiment, they were yet again forced back and rallied, after just a few minutes.