105 Artemis is a main-belt asteroid that was discovered by J. C. Watson on September 16, 1868, at Ann Arbor, Michigan.

Although it shares a similar orbit to the Phocaea family of S-type asteroids, its classification means 105 Artemis is not a member.

[13] Photometric measurement of this asteroid made in 2010 at Organ Mesa Observatory in Las Cruces, New Mexico, produced an irregular light curve with a period of 37.150 ± 0.001 hours.

[14] Refined observations by the Arecibo Observatory, reported in 2006, showed a complex surface with varying albedo.

Analysis of the spectra of 105 Artemis shows the presence of hydrated minerals at some rotation angles, but not at others.