The 105th was formed in response to President Lincoln's July 1862 Proclamation 121 which requested 300,000 volunteers from throughout the Union to serve for three years.
The regiment was attached to Ward's Brigade, Dumont's 12th Division, Army of the Ohio, to November 1862.
Ward's Brigade, Post of Gallatin, Tennessee, Department of the Cumberland, to June 1863.
Ward's Brigade, Post of Nashville, Tennessee, Department of the Cumberland, to January 1864.
1st Brigade, 1st Division, XI Corps, Army of the Cumberland, to April 1864.