The 105th New York Infantry was organized at LeRoy, New York beginning in November 1861 and mustered in for three years service on March 28, 1862 under the command of Colonel James M. Fuller.

The regiment was attached to Duryea's Brigade, Military District of Washington, to May 1862.

1st Brigade, 2nd Division, III Corps, Army of Virginia, to September 1862.

1st Brigade, 2nd Division, I Corps, Army of the Potomac, to March 1863.

Picket duty on the Shenandoah and at Front Royal, Va., until June 10.