The combined events were responsible for an estimated 20,000 deaths, of which some 15,000 occurred in Ramla alone, and caused damage throughout Greater Syria, including Palestine, where a tsunami devastated the Mediterranean coast, in Egypt and the Arabian Peninsula, and in areas to the east along the Euphrates such as al-Rahba and Kufa.

[1] The earthquake's effects were seen from as far north as Banias at the southern foot of Mount Hermon, to the Hejaz region of modern-day Saudi Arabia.

[2] Alarm was caused at Saint Catherine's Monastery on the Sinai Peninsula, and there was damage in the ancient city of Tinnis in the Nile delta, but not farther to the west along the Egyptian coast in Alexandria.

Seismologist Nicholas Ambraseys described one account of the effects at Ramla as destructive and with a large loss of life (15,000 deaths, 200 of which were boys at a school).

In 1458, another event again affected the southern Dead Sea area, this time causing a 2.2 m (7 ft 3 in) left-lateral offset at Qasr at-Tilah ("Tilah Castle", a Roman or Early Byzantine square fort, ca.