The 10 October 2008 Orakzai bombing occurred when a suicide bomber drove and detonated a pick-up truck packed with 300 kg of explosives into a meeting of 600 people, killing 40 instantly and injuring 81, although the toll later rose to 110 as many died in hospitals.

At the time of the attack, the Ali Khel tribesmen had gathered to discuss ways to evict the Taliban from the region.

The tribesmen initially left, although a political agent summoned a grand jirga of all 18 tribes of the Orakzai Agency on 30 September to clear the area of the Taliban by a lashkar, or local militia.

The Ali Khel tribe then returned to the area where they held a jirga on 7 October to take collective action against the Taliban along with representatives of the Ahle Sunnat Wal Jamaat, which is another name for Sipah-e-Sahaba Pakistan.

On 10 October, the tribesmen gathered at Khadizai village to destroy the local Taliban headquarters and homes of people sheltering the militants.