The 110th Cavalry Regiment was a regiment in the United States Army National Guard and was part of the Massachusetts Army National Guard.

Constituted 1 June 1921 in the Massachusetts National Guard as the 110th Cavalry, assigned to the 23rd Cavalry Division, and partially organized as follows- Reorganized 10 June 1937 and allotted to the National Guard of Massachusetts and Connecticut; concurrently Regimental Headquarters reorganized and federally recognized at West Hartford, Connecticut; remainder of regiment organized as follows- Relieved from the 22nd Cavalry Division and assigned to the 21st Cavalry Division 1 April 1939. allotted to the Massachusetts National Guard 9 May 1940 and recognized as follows- Relieved from the 21st Cavalry Division, converted and redesignated as the 180th Field Artillery Regiment (United States) 9 October 1940.

The Shield is yellow for cavalry.

The crossed guidons are those reputed to have been presented by Governor Edward Everett to the National Lancers.

the fleurs-de-lis represents service in France during World War I while the red mullet was the distinguishing symbol used by the 102nd machine Gun Battalion during the war.