In December 1937, the 110th division participated in fighting at Suzhou Creek, a part of the Battle of Shanghai.

[2] During that period, the division was mostly deployed on the north of Hebei province with the headquarters in Tianjin.

In January 1938, the headquarters were moved to Baoding and zone of responsibility changed to the southern part of Hebei province.

As Japanese forces were stretched thin, the 110th division participated in numerous and ultimately unsuccessful anti-guerilla operations against the Shanxi-Chahar-Hebei Communist Stronghold in North China.

The division returned to Luoyang and Ye County, staying there until the surrender of Japan on 15 August 1945.