The 110th Maneuver Enhancement Brigade unofficially descends from the 3rd Infantry Regiment, Missouri National Guard, first organized with that designation in 1886, but officially is a descendant of the 110th Engineer Regiment, which was first organized in 1917 during World War I as a part of the 35th Division.

The 110th Engineer Regiment fought in the Meuse-Argonne offensive in the closing months of World War I, arrived at the port of New York on 19 April 1919 aboard the USS Von Steuben, and was demobilized on 3 May 1919 at Fort Riley, Kansas.

The 110th Engineer Regiment was constituted in the National Guard in 1921, assigned to the 35th Division, and allotted to Missouri.

It was organized on 1 October 1921 at Kansas City, Missouri, by redesignation of the 3rd Engineers, Missouri National Guard, which was originally organized and federally recognized on 14 May 1918 as the 7th Infantry (state troops), redesignated as the 3rd Infantry on 6 August 1920, and reorganized as the 3rd Engineers on 1 May 1921.

[2] The regiment also maintained a 55-acre park called the "Military Country Club" in the Knobtown neighborhood southeast of Kansas City proper near Raytown for the use of the officers and men, with a ten-target rifle range, a twelve-acre lake, and a stable of saddle horses.