The 110th Ohio Infantry was organized at Camp Piqua in Piqua, Ohio, and mustered in for three years service on October 3, 1862, under the command of Colonel Joseph Warren Keifer.
The regiment was attached to Railroad Division, Clarksburg, Western Virginia, Middle Department, to January 1863.
Milroy's Command, Winchester, Va., VIII Corps, Middle Department, to March 1863.
1st Brigade, 2nd Division, VIII Corps, Middle Department, to June 1863.
2nd Brigade, 3rd Division, III Corps, Army of the Potomac, to March 1864.
The 110th Ohio Infantry mustered out of service at Washington, D.C. on June 25, 1865.
Moved to Zanesville, Ohio, October 19; thence to Parkersburg, Va.
Expedition to Winchester December 28, 1862, to January 1, 1863, and duty there until June.
Retreat to Harper's Ferry June 15–16, thence to Washington, D.C., July 1–4.
Moved to Frederick City, Md., and joined Army of the Potomac July 5.