At least 40,000 people were killed in the earthquake; a number contested by historians due to the small population in the area at the time.

Apart from Marash, the earthquake also caused destruction in Elbistan, Sis, Mopsuestia, Keysun, Sümeysat (Samsat), Hısn-ı mansûr (Adıyaman), Raban, Edessa, Antioch, Harran, Aleppo, Azaz, Esârib, Zerdana and Balis.

William of Tyre also records that this earthquake caused the most damage in the coastal region of Cilicia, Isauria, and Northern Syria.

[6] Walter the Chancellor who was in Antioch documented many city residents sought refuge in tents built on courtyards, gardens, groves and abandoned dwellings.

Fulcher of Chartres reported most houses in towns around the Antioch region were razed to the ground, killing its residents.

[7] Damage in Aleppo was limited to some collapsed homes in the city center and upper district where some residents died.