The regiment is named for the city of Macerata and part of the Italian Army's infantry arm.

The regiment was reformed during World War II and assigned to the 153rd Infantry Division "Macerata".

In 1992 the regiment was reformed as a battalion sized training unit in Fano, which remained active until 2000.

Both regiments consisted of three battalions, which each fielded four fusilier companies and one machine gun section.

In October 1918 the brigade fought in the Battle of Vittorio Veneto and after the breakthrough through the Austro-Hungarian lines advanced to the Livenza and then Tagliamento rivers.

[2][4] For their conduct during the last year of the war both regiments of the brigade were awarded a Silver Medal of Military Valor.