Following the English Reformation, religious art came to be regarded as a form of idolatry and many works were obliterated or destroyed; for this reason, some of the faces in the Piccotts End murals were mutilated and the paintings subsequently covered over by whitewash.

The art historian E. Clive Rouse has noted that the murals exhibit a technique of woodcut illustration dating from the late 15th and early 16th centuries, suggesting the influence of the artistic style of the Low Countries.

[1][3] The wall paintings consist of five panels, arranged in a type of iconostasis, resembling a large screen covered with icons, set in tiers.

On the extreme right is a badly damaged image of Saint Clement, the third Pope with a symbolic anchor on each shoulder and the Papal cross.

[1] It has been suggested that some of the symbolism contained in the wall paintings indicate connections with the doctrines of Catharism, a sect considered heretical by the Catholic Church.

[6][7] In 2014 a local conservation charity, the Dacorum Heritage Trust, launched an appeal to raise funds to buy the property.