[1] It was built in the late 16th century by John Crewe, a tanner, whose sons Randolph and Thomas both served as the Speaker of the House of Commons.
The original timber-framed, close-studded façade has been concealed by alterations during the late 17th century; these include the addition of small-paned casement windows, some of which contain old heraldic stained glass.
[2][3] Founded by William Malbank, the first baron of Nantwich, in 1083–84, the hospice was a religious house which accommodated sick or infirm travellers and gave alms to the poor.
[4][5][6] It was dissolved in 1548; on 11 November of the following year, Edward VI granted "a House and manse formerly called the Chapel of St. Nicholas", together with associated land and property, to Sir Thomas Bromley of Nantwich, a justice of the King's Bench.
[8][11] The Mainwarings were one of the prominent gentry families in Nantwich, having owned land there since the 14th century, and were also involved in the salt-making industry.
[8] John Crewe was the landlord of the property on Waterlode where the 1583 fire started "through negligence of undiscreet persons brewing", which destroyed much of the centre of the town, but spared the end of Hospital Street.
An 18th-century extension on the east (left) side is in painted brick and faces onto a passageway; the rear of the building also dates from the 18th century.
[1][8] Stone steps lead to the door, which is headed by an ogee-arched moulding, with paired quatrefoil decorations above surmounted by a cornice.
[4][20][21] The main section of the house also has four sash windows to the ground floor, dating from the late 18th century.