The 151st New York Infantry was organized at Lockport, New York, and mustered in for three years service on October 22, 1862, under the command of Colonel William Emerson.

The regiment was attached to the Defenses of Baltimore, Maryland, VIII Corps, Middle Department, to January 1863.

3rd Provisional Brigade, French's Division, VIII Corps, to July 1863.

1st Brigade, 3rd Division, III Corps, Army of the Potomac, to April 1864.

The 151st New York Infantry mustered out of service at Washington, D.C., on June 26, 1865.

Left New York for Baltimore, Maryland, October 23, 1862.

Duty at Baltimore, until April 22, 1863, and in the Middle Department until June.

Pursuit of Lee to Manassas Gap, Virginia, July 5–24.

Jerusalem Plank Road, Weldon Railroad, June 22–23.

Sheridan's Shenandoah Valley Campaign August 7 – November 28.