The 152nd New York Infantry was organized at Mohawk, New York, and mustered in for three years service on October 14, 1862, under the command of Colonel Leonard Boyer.

The regiment was attached to Provisional Brigade, Abercrombie's Division, Defenses of Washington, to February 1863.

1st Brigade, 1st Division, VII Corps, Department of Virginia, to July 1863.

1st Brigade, 2nd Division, II Corps, Army of the Potomac, to March 1864.

The 152nd New York Infantry mustered out of service at Washington, D.C., on June 13, 1865.

Expedition from White House to Bottom's Bridge July 1–7.

Duty at New York City July 16 to October 18.

Jerusalem Plank Road, Weldon Railroad, June 22–23, 1864.

Boydton Plank Road, Hatcher's Run, October 27–28.

Boydton Road and White Oak Ridge March 29–31.

The regiment lost a total of 161 men during service.